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Human Growth Hormone (growth hormone, GH, HGH, somatotropin, somatropin) — a peptide hormone of the anterior pituitary, which is used in sports for the formation of muscle relief. Growth hormone or somatotropin (from. Latin soma - body) got its name for that young people, it causes a marked acceleration in linear (in length). Growth was mainly due to the growth of the long bones of the limbs.
The baseline concentration of growth hormone in the blood is 1-5 ng/ml, while the peaks may rise to 10-20 and even 45 ng/ml. It was first isolated in 1956. Secretes growth hormone in pituitary gland in response to signals from the hypothalamus. Usually, after twenty years, the production of this hormone by the body decreases. The aging process is directly related to the rate of release of growth hormone. On average, after 20 years, every 10 years the level of production drops by 15%.
Growth hormone has no sexual differences. That is, its level is equal in men and women. Despite the fact that the use of preparations containing growth hormone, banned VADO (world anti-Doping Organization), HGH preparations are available in Thailand.
- Anabolic effect - causes muscle growth
- Anti-catabolic action - inhibits muscle breakdown
- Reduces body fat
- Improves energy use
- Speeds healing
- Has the effect of rejuvenating
- Stimulates re-growth of internal organs (atrophied with age)
- Causes bone growth and increases growth in young people up to 26 years (until the closure of areas of growth), strengthens bones
- Increases the level of glucose in the blood
Some of the effects the drug causes itself, but a large part of its effects is mediated by insulin-like growth factor IGF-1 (previously it was called somatomedin C), which is produced by the action of growth hormone in the liver and stimulates the growth of most internal organs. Almost all of the effects of growth hormone in sports associated with the action of IGF-1.
The secretion of growth hormone steadily decreases with age. It is minimal in the elderly, who have reduced as a baseline, and frequency and amplitude of the peaks of secretion. A baseline level of growth hormone is maximal in early childhood, the amplitude peaks of maximum secretion during the period of teenagehood a rapid linear growth as well as during puberty. Circadian rhythms in the secretion of HGH:
The secretion of growth hormone and many other hormones that occurs periodically and has several peaks during the day (usually peak secretion occurs every 3-5 hours). The highest peak is observed in the night, about an hour after falling asleep.
Initially, preparations of growth hormone began to be used for medical purpose, however, almost at the same time this hormone was widespread in sports, because of its ability to increase muscle mass and reduce body fat. The first preparation of HGH was a pituitary corpses, and only in 1981 was made a recombinant drug somatotropin.
In 1989, the bovine growth hormone was banned by the Olympic Committee. Despite the fact that the use of growth hormone in athletic purposes is prohibited, in the last decade, sales of the drug increased multiple times. Mainly, the growth hormone used in sports, especially in bodybuilding, where it's combined with other anabolic drugs.
The main reason for the popularity of HGH in sports is the ability to reduce the amount of subcutaneous fat. In addition, studies have shown that taking growth hormone leads to increased lean muscle mass, connective tissues and increase volume of muscle cells due to the accumulation of fluid.
Another useful effect of growth hormone - decrease the frequency of injuries. This is due to its ability to strengthen bone and connective (tendons, cartilage) tissue. Growth hormone accelerates healing and tissue regeneration after injuries.
It should be noted that the use of HGH in powerlifting is pointless, since in the experiment it was found that it does not increase power performance. Somatotropin also increases stamina and performance, and on the contrary, a decrease in the threshold of fatigue and slowing the recovery, so growth hormone are useless for athletes of such sports, where these indicators.
The General conclusion is that growth hormone can be used in sports with the purpose of obtaining relief.
high efficiency, low incidence of side effects, the drug does not affect the function of the penis and the potency does not cause androgenic effects and does not require the PCT after a monthly rate of total weight increased slightly (3-4 kg), and in some cases not at all change is associated with large losses of fat.
the high cost of drugs is about 4-5 thousand dollars per course.
Because HGH is produced naturally in the human body, side effects of HGH are rare. Side effects occur mainly in those cases where growth Hormone is used in doses higher than recommended and longer time than specified by the experts. In practice, there are following side effects of human growth Hormone (frequency of occurrence):
Tunnel syndrome is manifested by pain and numbness in the extremities. This is due to the fact that increasing amounts of muscle compress the peripheral nerves. This side effect is not dangerous and is quickly resolved after reducing the dose.
The accumulation of fluid, hardly a side effect, because accumulation of fluid is in the muscles, giving them a large size and elasticity. In General, the minimal recoil phenomenon after the end of the course.
High blood pressure - is eliminated either by reduction of the dose of HGH, or use of antihypertensive drugs.
Inhibition of the function of the thyroid gland - is subjective does not manifest itself, because the oppression is too low. For its elimination and increase the efficiency of the cycle is used Thyroxine at a dose of 25 mcg per day. After discontinuation of growth hormone, thyroid function is fully restored.
Hyperglycemia - increase of glucose level in the blood. Eliminated insulin or drugs that stimulate the pancreas (gliclazide). Does not usually require additional measures and is fully reversible. You can also take supplements with alpha lipoic acid, it restores insulin sensitivity.
Acromegaly - the disease occurs due to pronounced abuse of drugs of growth hormone. When applied correctly, is not found.
Hypertrophy of the heart and other organs occurs only in the case of prolonged use of HGH in large doses. When applied correctly, is not found.
An increase in the abdomen - it is widely believed that growth hormone can increase the abdomen due to hyperplasia of the internal organs (as the intestines and organs have receptors for IGF-1). There is currently no scientific evidence of this fact, however, bright examples of changes of the abdomen in the environment of professional bodybuilders associated with it. However, practical experience of most athletes shows that the classic courses of growth hormone not lead to growth of the abdomen. Experts believe that the enlargement of the abdomen (in the English Internet common the term "GH gut") has several natural chemical effects and it is possible when using large doses of GH in combination with insulin, steroids, along with the consumption of large amounts of food.
Impact on the potency and function of the penis - HGH has no negative impact on sexual function.
Suppression of secretion of own growth hormone - Professor Elmer M. Cranton, M. D. conducted a study on more than 100 patients, which was not discovered suppress its own secretion.
Cancer - growth hormone causes a dramatic acceleration of the division of tumor cells, so the researchers become concerned about whether the growth hormone to the muscles. There were a retrospective study, which was attended by people treated with growth hormone, the frequency of neoplastic processes they are not statistically different from the rest of the population that can speak about the absence of carcinogenic effects of growth hormone.
Growth hormone rarely causes side effects if applied in moderate doses. Almost all side effects are reversible. At the same time, it was clearly proven that preparations of HGH can rejuvenate the body to improve physical fitness, reduce bad cholesterol, improve skin, strengthen bones and ligaments and many other positive effects.
The main regulators of secretion of the growth hormone - peptide hormones of the hypothalamus (somatostatin and somatoliberin), which are secreted by neurosecretory cells of the hypothalamus into the portal veins of the pituitary and act directly on somatotrope. However, the balance of these hormones and on secretion of growth hormone is affected by many physiological factors. Scientists have proved that the level of secretion of growth hormone can be increased by 3-5 times, without the use of hormonal methods.
Peptides are the most potent stimulators of growth hormone, increase the concentration 7-15 times the cost of equivalent course several times below:
GHRP-2
GHRP-6
GRF (1-29)
CJC-1295
Ipamorelin
HGH Frag (176-191) - fragment
Peptides (from the Greek. πεπτος - nourishing) - a family of substances whose molecules are built from residues of α-amino acids linked in a chain peptide (amide) bonds. They are natural or synthetic compounds containing tens, hundreds or thousands of Monomeric units - amino acids. This class is very diverse and does in the body a variety of regulatory functions. In this article we will consider only those peptides that are used in sports for the correction of physical indicators.
Currently on the market of Thailand more and more often there are peptides, which are stimulants of growth hormone. The most popular peptides in bodybuilding in Thailand:
From the group of Ghrelin (GHRP): (create a pronounced GR peak concentration immediately after injection, irrespective of the time of day and the presence of somatostatin in the blood).
GHRP-6 and Hexarelin
GHRP-2
Ipamorelin
From the group of growth Hormone releasing hormone (GHRH): (introduction in the body causes a wave-like increase in the concentration of which will be weak in the hours when the natural secretion of GRS was reduced by somatostatin, and high during the natural increase in the concentration of GR (e.g. during the night). In other words GHRH increases the secretion of GRS, without disturbing the natural process curve.)
GRF (1-29) Sermorelin
CJC-1295
HGH Frag (176-191) is a fragment of growth hormone (fat burner)
Many questions arise, why use a new peptide substance, if there is artificial human growth hormone? The answer is simple: peptide stimulants have several compelling advantages.
Peptides is significantly cheaper than growth hormone. The cost of a similar course will be several times lower.
Different mechanisms of action and half-lives allow us to manipulate the concentration curve for optimal anabolic response.
Different effects on hunger and metabolism, allows you to give preference to those or other substances.
At the moment the production and distribution of peptides is not regulated by law, so it is safe to order online.
Quickly and completely dissolved, so there is no fear for doping control.
Peptides, as well as classic growth hormone is easy to check for authenticity. It's enough to pass tests on the level of somatotropin in plasma after drug administration.
Growth hormone can be used by both men and women over the age of 20 years (the more young people may experience asymmetrical development of bones) to reinforce the prominence of the musculature. The total mass increases slightly, this happens as a result of large losses of fat.
Side effects during and after a course are almost not observed, they usually are reversible.
The course is contraindicated for people with diabetes (growth hormone increases the amount of glucose in the blood), caution should be used in hypertension (human growth hormone may increase it). Before using the drug you must consult a doctor.
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